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Main Profile

Full Name and Degrees: 
Jeffrey A. Whitsett, M.D.
Member Role: 
Lead Principal Investigator
Institutional affiliation: 

UNDERGRADUATE  EDUCATION          1969      Colgate University, Hamilton, NY, B.A. Chemistry

MEDICAL EDUCATION                          1973      Columbia University, New York, NY, M.D.

CLINICAL TRAINING                             1973-1974           Internship - Mt. Sinai Hospital, New York, NY

                                                            1974-1976           Residency - Mt. Sinai Hospital, New York, NY

POSTGRADUATE TRAINING                 1976-1977           Neonatology Fellowship - Children's Hospital                                                                                                Medical Center, University of Cincinnati College                                                                                          of Medicine


ACADEMIC                                           2009      Executive Director, Perinatal Institute, CCHMC

                                                            2003      Chief, Section of Neonatology, Perinatal and Pulmonary                                                                          Biology, CCHMC

                                                            1995      Director, Divisions of Neonatology and Pulmonary                                                                                  Biology, CCHMC

                                                           1994      Vice Chairperson for Research, Department of                                                                                       Pediatrics, CCHMC

                                                           1988      Director, Division of Pulmonary Biology, CCHMC

                                                           1985      Professor of Pediatrics, and Pharmacology and Cell                                                                               Biophysics, University of Cincinnati College of Medicine

                                                           1984      Director Research, Newborn Division

                                                           1981      Associate Professor of Pediatrics

                                                           1981     Research Associate, Division of Cell Biology, Institute                                                                            for Developmental Research

                                                           1978      Assistant Professor of Pediatrics

                                                           1977      Instructor in Research Pediatrics, University of                                                                                       Cincinnati

CLINICAL APPOINTMENT                   Children's Hospital Medical Center, Cincinnati, OH, Director                                                                      Neonatology, University Hospital, Cincinnati, OH


I am a clinician-scientist and senior investigator with a long-standing interest in lung development and disease and I have been continuously funded by the NIH for more than 35 years. Our laboratory discovered surfactant proteins B and C, cloned the genes encoding the surfactant proteins A, B, C, and D, Scgb1a1, TTF-1 and others and utilized transgenic mouse models to delete and mutate these genes in transgenic mice. We identified transcriptional networks regulating lung morphogenesis and perinatal lung maturation contributing to the understanding of the roles of TTF-1, CEBPα, SOX2, SOX17, FOXA1, FOXA2, FOXA3, SPDEF, KLF5, CDC42 and others using both in vitro and in vivo methods. We identified multiple transcription factors regulating goblet cell differentiation airway epithelial cells including critical role of SPDEF, FOXA3 and airway goblet cells controlling innate immunity. We produced transgenic mouse models for conditional deletion and expression of genes involved in lung development, disease, and repair. We have generated transgenic models of pulmonary adenocarcinoma and explored the role of transcription factors mediating pulmonary adenocarcinoma in vivo and in vitro. We utilized RNA-Seq, microarray, Chip-Seq in the application of Nex-Gen sequencing and bioinformatics to identify and understand networks involved in the regulation of lung development and disease using clinical sample, as well as in vitro and in vivo models. I have a long interest in training both in the clinical setting in “Neonatology” and in “Pulmonary Biology” and have contributed to the direct training of more than 80 graduate or post-graduate students in my laboratory. The scope of my work is represented in several recent reviews. Initial discoveries from my laboratory provided early insights into the genes and proteins critical for surfactant function including ABCA3, SFTPC, SFTPB, SFTPA, SFTPD. 

research focus: 
Recent publications: 
Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Li E, Ustiyan V, Wen B, Kalin GT, Whitsett JA, Kalin TV, Kalinichenko VV.Dev Dyn. 2021 Jan 11. doi: 10.1002/dvdy.298. Online ahead of print.PMID: 33428297 Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. Du Y, Ouyang W, Kitzmiller JA, Guo M, Zhao S, Whitsett JA, Xu Y.Am J Respir Cell Mol Biol. 2021 Jan;64(1):146-149. doi: 10.1165/rcmb.2020-0308LE.PMID: 33385216 In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. Wen B, Li E, Ustiyan V, Wang G, Guo M, Na CL, Kalin GT, Galvan V, Xu Y, Weaver TE, Kalin TV, Whitsett JA, Kalinichenko VV.Am J Respir Crit Care Med. 2021 Feb 15;203(4):471-483. doi: 10.1164/rccm.201909-1836OC.PMID: 32877203
Division of Pulmonary Biology 3333 Burnet Avenue Cincinnati, OH 45229-3039
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