jwhitsett
Main Profile
UNDERGRADUATE EDUCATION 1969 Colgate University, Hamilton, NY, B.A. Chemistry
MEDICAL EDUCATION 1973 Columbia University, New York, NY, M.D.
CLINICAL TRAINING 1973-1974 Internship - Mt. Sinai Hospital, New York, NY
1974-1976 Residency - Mt. Sinai Hospital, New York, NY
POSTGRADUATE TRAINING 1976-1977 Neonatology Fellowship - Children's Hospital Medical Center, University of Cincinnati College of Medicine
ACADEMIC 2009 Executive Director, Perinatal Institute, CCHMC
2003 Chief, Section of Neonatology, Perinatal and Pulmonary Biology, CCHMC
1995 Director, Divisions of Neonatology and Pulmonary Biology, CCHMC
1994 Vice Chairperson for Research, Department of Pediatrics, CCHMC
1988 Director, Division of Pulmonary Biology, CCHMC
1985 Professor of Pediatrics, and Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine
1984 Director Research, Newborn Division
1981 Associate Professor of Pediatrics
1981 Research Associate, Division of Cell Biology, Institute for Developmental Research
1978 Assistant Professor of Pediatrics
1977 Instructor in Research Pediatrics, University of Cincinnati
CLINICAL APPOINTMENT Children's Hospital Medical Center, Cincinnati, OH, Director Neonatology, University Hospital, Cincinnati, OH
I am a clinician-scientist and senior investigator with a long-standing interest in lung development and disease and I have been continuously funded by the NIH for more than 35 years. Our laboratory discovered surfactant proteins B and C, cloned the genes encoding the surfactant proteins A, B, C, and D, Scgb1a1, TTF-1 and others and utilized transgenic mouse models to delete and mutate these genes in transgenic mice. We identified transcriptional networks regulating lung morphogenesis and perinatal lung maturation contributing to the understanding of the roles of TTF-1, CEBPα, SOX2, SOX17, FOXA1, FOXA2, FOXA3, SPDEF, KLF5, CDC42 and others using both in vitro and in vivo methods. We identified multiple transcription factors regulating goblet cell differentiation airway epithelial cells including critical role of SPDEF, FOXA3 and airway goblet cells controlling innate immunity. We produced transgenic mouse models for conditional deletion and expression of genes involved in lung development, disease, and repair. We have generated transgenic models of pulmonary adenocarcinoma and explored the role of transcription factors mediating pulmonary adenocarcinoma in vivo and in vitro. We utilized RNA-Seq, microarray, Chip-Seq in the application of Nex-Gen sequencing and bioinformatics to identify and understand networks involved in the regulation of lung development and disease using clinical sample, as well as in vitro and in vivo models. I have a long interest in training both in the clinical setting in “Neonatology” and in “Pulmonary Biology” and have contributed to the direct training of more than 80 graduate or post-graduate students in my laboratory. The scope of my work is represented in several recent reviews. Initial discoveries from my laboratory provided early insights into the genes and proteins critical for surfactant function including ABCA3, SFTPC, SFTPB, SFTPA, SFTPD.
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