Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts

Drs. Akhilesh Kumar, James Thomson, Igor Slukvin, and colleagues find that mesodermal pericytes and smooth muscle cells in human pluripotent stem cell cultures originate from a common endothelial and mesenchymal cell precursor, the mesenchymoangioblast. They show how different lineages of mural cells are specified from mesenchymoangioblasts and define stage- and lineage-specific markers for vasculogenic cells. [30May2017 Cell Reports]


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Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells

Drs. Finn Hawkins, Jason Rock, Darrell Kotton, and colleagues report that iPSC-derived lung epithelial cells originate from identifiable NKX2-1+ progenitors. [02May2017 The Journal of Clinical Investigation]

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Sorted iPSC-derived NKX2-1GFP+ cells exhibit lung progenitor potential and ability to form epithelial spheroids in 3D culture


“Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling” - Darrell Kotton

Drs. Katherine McCauley, Finn Hawkins, Darrell Kotton, and colleagues report that cyclical modulation of the canonical Wnt signaling pathway enables rapid directed differentiation of human iPSCs via an NKX2-1+ progenitor intermediate into functional proximal airway organoids. [30Mar2017 Cell Stem Cell]


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