“A Humanized Mouse Model Generated Using Surplus Neonatal Tissue” – Thomson (UW-M) Research Hub 05

Drs. Matthew Brown, Ying Zhou, James Thomson, and colleagues have created a humanized mouse model using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). [22Mar2018 Stem Cell Reports]

Link to full article:

http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30102-4

Publication: “Regeneration of the Lung Alveolus by an Evolutionarily Conserved Epithelial Progenitor”

Drs. Edward Morrisey, William Zacharias, David Frank, et al. demonstrate alveolar epithelial progenitors’ contribution to functional alveolar epithelial regeneration. [08Mar2018 Nature]

Link to full article:

https://www.nature.com/articles/nature25786

AEPs display an evolutionarily conserved response to Wnt and Fgf signaling.

 

Request for Information (RFI): Strategically Critical Resources or Infrastructures Recommended for NHLBI Support Using the R24/U24 Grant Mechanisms

The NHLBI is requesting information on needs for resources or infrastructure to access biospecimens, disease models (cell lines or model organisms), production capabilities, information or data, or standardization of data/tools of relevance to the research mission of the NHLBI. Of particular interest are needs at a national level that could be supported under R24/U24 grant mechanisms.

Publication: “Dye-Independent Methods Reveal Elevated Mitochondrial Mass in Hematopoietic Stem Cells”

Drs. Hans-Willem Snoeck, Mariana Justino de Almeida, Larry Luchsinger, and colleagues correct the erroneous impression that HSCs have low mitochondrial content. HSCs exhibit high mitochondrial content yet possess limited respiratory and turnover capacity. [07Dec2017 Cell Stem Cell]

Link to full article:

http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30454-X

 

Sustained miRNA Delivery from an Injectable Hydrogel Promotes Cardiomyocyte Proliferation and Functional Regeneration after Ischaemic Injury

Drs. Edward Morrisey, Leo Wang, Ying Liu, and colleagues report on an injectable hyaluronic acid hydrogel for local and sustained delivery of miR-302 mimics to the heart. [27Nov2017 Nature Biomedical Engineering]

 

Link to full article:

https://www.nature.com/articles/s41551-017-0157-y

Hydrogel assembly and miR-302 interactions.

 

Training Opportunity: “Human Induced Pluripotent Stem Cells and Their Differentiation into Endoderm and Lung-Progeny” at Boston Medical Center (April 9-13, 2018)

The Center for Regenerative Medicine (CReM) at Boston University Medical Center is offering a five-day course that will focus on deriving, maintaining, characterizing and differentiating human induced pluripotent stem cells (hiPSCs). Small class size will enable researchers to learn the entire process of reprogramming from somatic cell preparation, to reprogramming methodologies, iPSC identification, isolation and characterization, and current approaches to their directed differentiation into endodermal and lung lineages.

“Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung”

Drs. Edward Morrisey, Jarod Zepp, William Zacharias, and colleagues report on the functional pathways that define the cellular and molecular framework of lung mesenchymal niches and reveal the functional importance of developmental pathways in promoting self-renewal versus a pathological response to tissue injury. [07Sep2017 Cell]

 

Link to full article:

http://www.sciencedirect.com/science/article/pii/S009286741730870X

“Cardiopatch Platform Enables Maturation and Scale-up of Human Pluripotent Stem Cell-derived Engineered Heart Tissues”

Drs. Nenad Bursac, Ilya Shadrin, Brian Allen, and colleagues report on a “Cardiopatch” platform for 3D culture and maturation of hiPSC-CMs (after 5 weeks of differentiation) showing robust electromechanical coupling, consistent H-zones, I-bands, and evidence for T-tubules and M-bands. [28Nov2017 Nature Communications]

Link to full article:

https://www.nature.com/articles/s41467-017-01946-x

 

“EMC3 Coordinates Surfactant Protein and Lipid Homeostasis Required for Respiration”

Drs. Jeffrey Whitsett, Xiaofang Tang, John Snowball, and colleagues report on transcriptomic, lipidomic, and proteomic analyses demonstrating that EMC3 coordinates the assembly of lipids and proteins that is necessary for surfactant synthesis and lung function at birth. [30Oct2017 The Journal of Clinical Investigation]

Link to full article:

https://www.jci.org/articles/view/94152

CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle

Drs. Jianyi (Jay) Zhang, Wuqiang Zhu, Meng Zhao, and colleagues report that CCND2 overexpression activates cell-cycle progression in hiPSC-CMs to enhance potency for myocardial repair as evidenced by remuscularization of injured myocardium. [10Oct2017 Circulation Research]

Article was selected as a finalist for "The Melvin L. Marcus Young Investigator Award in Basic Cardiovascular Sciences” at the 2017 American Heart Association Meeting in Anaheim, California (Nov 9-16, 2017).

Link to full article:

Pages

Copyright ©2016 NHLBI Progenitor Cell Translational Consortium.

University of Maryland School of Medicine logo

National Heart Blood and Lung Institute logo