Neural Crest State Activation in NRAS Driven Melanoma, but not in NRAS-driven Melanocyte Expansion

Drs. Leonard Zon, Alicia McConnell, Jeffrey Mito, and colleagues demonstrated that NRASQ61R induces extensive melanocyte expansion during zebrafish development. [06Jun2018 Developmental Biology]

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Neural Crest State Activation in NRAS Driven Melanoma, but not in NRAS-driven Melanocyte Expansion

"Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28"

Drs. Longfei Wang, R. Grant Rowe, George Daley, and colleagues report on the selective pharmacologic inhibition of individual domains of LIN28 and provide a foundation for therapeutic inhibition of the let-7 biogenesis pathway in LIN28-driven diseases. [05June2018 Cell Reports]

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Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells

Drs. Sarah K. Tasian, Jessica A. Casas, Stella Chou, and colleagues assessed whether MEK, JAK, and PI3K/mTOR kinase inhibitors could inhibit myeloproliferation and aberrant signaling in iPSC-derived hematopoietic progenitors with PTPN11 E76K or CBL Y371H mutation and demonstrated differential sensitivity. [08June2018 Leukemia]

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“Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential” – Thomson (UW-M) Research Hub 05

Drs. Mi Ae Park, Akhilesh Kumar, James Thomson, and colleagues reported on the generation of definitive lymphomyeloid progenitors and lymphoid cells from hPSCs for immunotherapy through enhancing arterial programming of HE. [22May2018 Cell Reports]

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Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential

“A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development” – Daley (BCH) Research Hub 03

Drs. George Daley, Marcella Cesana, Michael Guo, and colleagues reported that hematopoietic stem cells (HSCs) manifest distinct alternative splicing patterns in key hematopoietic regulators. [05Apri2018 Cell Stem Cell]

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A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development

“Cardiac Recovery via Extended Cell-Free Delivery of Extracellular Vesicles Secreted by Cardiomyocytes Derived from Induced Pluripotent Stem Cells”

 

Drs. Bohao Liu, Benjamin Lee, Gordana Vunjak-Novakovic, and colleagues demonstrated that sustained delivery of extracellular vesicles, secreted by iPSC-derived cardiomyocytes, promote cardiac recovery after myocardial infarction. [23April2018 Nature Biomedical Engineering]

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NHLBI 70th Anniversary Lecture Series

To commemorate the National Heart, Lung, and Blood Institute’s 70th anniversary, lectures throughout 2018 will feature leaders in areas of high scientific priority.

Upcoming lectures at the NIH main campus:

  • Dr. Eugene Braunwald, Brigham and Women’s Hospital

    • Thursday, June 28, 2018

  • Dr. Jonathan Samet, Colorado School of Public Health

    • Wednesday, September 12, 2018

  • Dr. Lisa Schwartz and Dr. Steven Woloshin, Dartmouth Institute

Publication: Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Yang and colleagues (Cardoso’s lab) report on how basal cells emerge during development  and how a subset of  these progenitors mediate the pathological alveolar remodeling after influenza injury.

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Y. Yang, P. Riccio, M. Schotsaert, M. Mori, J. Lu, D-K. Lee ,A. Garcıa-Sastre, J. Xu, and W.V. Cardoso. Developmental Cell 44, 752–761, March 26, 2018

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Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

Darrell Kotton, Ed Morrisey, and colleagues show that human pluripotent stem cell-derived airway epithelial spheres contain basal and secretory airway cells.

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Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

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