Sustained miRNA Delivery from an Injectable Hydrogel Promotes Cardiomyocyte Proliferation and Functional Regeneration after Ischaemic Injury

Drs. Edward Morrisey, Leo Wang, Ying Liu, and colleagues report on an injectable hyaluronic acid hydrogel for local and sustained delivery of miR-302 mimics to the heart. [27Nov2017 Nature Biomedical Engineering]

 

Link to full article:

https://www.nature.com/articles/s41551-017-0157-y

Hydrogel assembly and miR-302 interactions.

 

Training Opportunity: “Human Induced Pluripotent Stem Cells and Their Differentiation into Endoderm and Lung-Progeny” at Boston Medical Center (April 9-13, 2018)

The Center for Regenerative Medicine (CReM) at Boston University Medical Center is offering a five-day course that will focus on deriving, maintaining, characterizing and differentiating human induced pluripotent stem cells (hiPSCs). Small class size will enable researchers to learn the entire process of reprogramming from somatic cell preparation, to reprogramming methodologies, iPSC identification, isolation and characterization, and current approaches to their directed differentiation into endodermal and lung lineages.

“Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung”

Drs. Edward Morrisey, Jarod Zepp, William Zacharias, and colleagues report on the functional pathways that define the cellular and molecular framework of lung mesenchymal niches and reveal the functional importance of developmental pathways in promoting self-renewal versus a pathological response to tissue injury. [07Sep2017 Cell]

 

Link to full article:

http://www.sciencedirect.com/science/article/pii/S009286741730870X

“Cardiopatch Platform Enables Maturation and Scale-up of Human Pluripotent Stem Cell-derived Engineered Heart Tissues”

Drs. Nenad Bursac, Ilya Shadrin, Brian Allen, and colleagues report on a “Cardiopatch” platform for 3D culture and maturation of hiPSC-CMs (after 5 weeks of differentiation) showing robust electromechanical coupling, consistent H-zones, I-bands, and evidence for T-tubules and M-bands. [28Nov2017 Nature Communications]

Link to full article:

https://www.nature.com/articles/s41467-017-01946-x

 

“EMC3 Coordinates Surfactant Protein and Lipid Homeostasis Required for Respiration”

Drs. Jeffrey Whitsett, Xiaofang Tang, John Snowball, and colleagues report on transcriptomic, lipidomic, and proteomic analyses demonstrating that EMC3 coordinates the assembly of lipids and proteins that is necessary for surfactant synthesis and lung function at birth. [30Oct2017 The Journal of Clinical Investigation]

Link to full article:

https://www.jci.org/articles/view/94152

CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle

Drs. Jianyi (Jay) Zhang, Wuqiang Zhu, Meng Zhao, and colleagues report that CCND2 overexpression activates cell-cycle progression in hiPSC-CMs to enhance potency for myocardial repair as evidenced by remuscularization of injured myocardium. [10Oct2017 Circulation Research]

Article was selected as a finalist for "The Melvin L. Marcus Young Investigator Award in Basic Cardiovascular Sciences” at the 2017 American Heart Association Meeting in Anaheim, California (Nov 9-16, 2017).

Link to full article:

“Manufacturing Cell Therapies: The Paradigm Shift in Health Care of This Century”

New National Academy of Medicine (NAM) Discussion Paper on translating progenitor cell research to Regenerative Medicine

Link to full article:

https://nam.edu/manufacturing-cell-therapies-the-paradigm-shift-in-health-care-of-this-century/

 

Lung Gene Expression Analysis (LGEA): An Integrative Web Portal for Comprehensive Gene Expression Data Analysis in Lung Development

Drs. Yina Du, Joseph Kitzmiller, Yan Xu, Jeffrey Whitsett, and colleagues share the Lung Gene Expression Analysis (LGEA) web portal for gene expression patterns in single cells, sorted cell populations and whole lung tissues. [May2017 Thorax]

Link to full article:

http://thorax.bmj.com/content/72/5/481

SLICE: Determining Cell Differentiation and Lineage Based on Single Cell Entropy

Drs. Minzhe Guo, Erik Bao, Jeffrey Whitsett, and colleagues developed SLICE, a novel algorithm that utilizes single-cell RNA-seq (scRNA-seq) to measure cellular differentiation and predict cell differentiation lineages. [20April2017 Nucleic Acid Research]

Link to full article:

https://academic.oup.com/nar/article/45/7/e54/2725372/SLICE-determining-cell-differentiation-and-lineage

“Functional Characterization of Human Pluripotent Stem Cell-Derived Arterial Endothelial Cells” – Thomson (UW-M) Research Hub 05

Drs. Jue Zhang, Li-Fang Chu, James Thomson, and colleagues report on derivation of arterial endothelial cells from human pluripotent stem cells that exhibit arterial-specific functions in vitro and in vivo. [08Jun2017 PNAS]

Link to full article:

http://www.pnas.org/content/early/2017/07/06/1702295114.full.pdf

Arterial-specific functional characterization of endothelial cells.

 

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