“Manufacturing Cell Therapies: The Paradigm Shift in Health Care of This Century”

New National Academy of Medicine (NAM) Discussion Paper on translating progenitor cell research to Regenerative Medicine

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Lung Gene Expression Analysis (LGEA): An Integrative Web Portal for Comprehensive Gene Expression Data Analysis in Lung Development

Drs. Yina Du, Joseph Kitzmiller, Yan Xu, Jeffrey Whitsett, and colleagues share the Lung Gene Expression Analysis (LGEA) web portal for gene expression patterns in single cells, sorted cell populations and whole lung tissues. [May2017 Thorax]

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SLICE: Determining Cell Differentiation and Lineage Based on Single Cell Entropy

Drs. Minzhe Guo, Erik Bao, Jeffrey Whitsett, and colleagues developed SLICE, a novel algorithm that utilizes single-cell RNA-seq (scRNA-seq) to measure cellular differentiation and predict cell differentiation lineages. [20April2017 Nucleic Acid Research]

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“Functional Characterization of Human Pluripotent Stem Cell-Derived Arterial Endothelial Cells” – Thomson (UW-M) Research Hub 05

Drs. Jue Zhang, Li-Fang Chu, James Thomson, and colleagues report on derivation of arterial endothelial cells from human pluripotent stem cells that exhibit arterial-specific functions in vitro and in vivo. [08Jun2017 PNAS]

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Arterial-specific functional characterization of endothelial cells.


Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts

Drs. Akhilesh Kumar, James Thomson, Igor Slukvin, and colleagues find that mesodermal pericytes and smooth muscle cells in human pluripotent stem cell cultures originate from a common endothelial and mesenchymal cell precursor, the mesenchymoangioblast. They show how different lineages of mural cells are specified from mesenchymoangioblasts and define stage- and lineage-specific markers for vasculogenic cells. [30May2017 Cell Reports]


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Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells

Drs. Finn Hawkins, Jason Rock, Darrell Kotton, and colleagues report that iPSC-derived lung epithelial cells originate from identifiable NKX2-1+ progenitors. [02May2017 The Journal of Clinical Investigation]

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Sorted iPSC-derived NKX2-1GFP+ cells exhibit lung progenitor potential and ability to form epithelial spheroids in 3D culture


“Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling” - Darrell Kotton

Drs. Katherine McCauley, Finn Hawkins, Darrell Kotton, and colleagues report that cyclical modulation of the canonical Wnt signaling pathway enables rapid directed differentiation of human iPSCs via an NKX2-1+ progenitor intermediate into functional proximal airway organoids. [30Mar2017 Cell Stem Cell]


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