“Dissociation, Cellular Isolation and Initial Molecular Characterization of Neonatal and Pediatric Human Lung Tissues”

Drs. Gautam Bandyopadhyay, Heidie Huyck, Ravi Misra, Jeffrey Whitsett, and colleagues report novel methods that simultaneously isolate four major pulmonary cell populations from pediatric human lung. [05Jul2018 American Journal of Physiology - Lung Cellular and Molecular Physiology]

 

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Dissociation, Cellular Isolation and Initial Molecular Characterization of Neonatal and Pediatric Human Lung Tissues

 

Can We Engineer a Human Cardiac Patch for Therapy?

Drs. Jianyi Zhang, Wuqiang Zhu, Milica Radisic, and Gordana Vunjak-Novakovic provide a compendium of state-of-the-art developments in the fields of cardiovascular tissue engineering and challenges associated with their clinical use. [05Jul2018 Circulation Research: Regenerative Cardiology Compendium]

 

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Can We Engineer a Human Cardiac Patch for Therapy?”

 

Jianyi Zhang, Wuqiang Zhu, Milica Radisic, and Gordana Vunjak-Novakovic

GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells

Drs. Chia-Min Liao, Somdutta Mukherjee, and colleagues reported that modulating GATA6 expression enhances the production of lung progenitors from human stem cell sources. [11Jun2018 JCI The Journal of Clinical Investigation]

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GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells

Neural Crest State Activation in NRAS Driven Melanoma, but not in NRAS-driven Melanocyte Expansion

Drs. Leonard Zon, Alicia McConnell, Jeffrey Mito, and colleagues demonstrated that NRASQ61R induces extensive melanocyte expansion during zebrafish development. [06Jun2018 Developmental Biology]

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Neural Crest State Activation in NRAS Driven Melanoma, but not in NRAS-driven Melanocyte Expansion

"Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28"

Drs. Longfei Wang, R. Grant Rowe, George Daley, and colleagues report on the selective pharmacologic inhibition of individual domains of LIN28 and provide a foundation for therapeutic inhibition of the let-7 biogenesis pathway in LIN28-driven diseases. [05June2018 Cell Reports]

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Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells

Drs. Sarah K. Tasian, Jessica A. Casas, Stella Chou, and colleagues assessed whether MEK, JAK, and PI3K/mTOR kinase inhibitors could inhibit myeloproliferation and aberrant signaling in iPSC-derived hematopoietic progenitors with PTPN11 E76K or CBL Y371H mutation and demonstrated differential sensitivity. [08June2018 Leukemia]

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“Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential” – Thomson (UW-M) Research Hub 05

Drs. Mi Ae Park, Akhilesh Kumar, James Thomson, and colleagues reported on the generation of definitive lymphomyeloid progenitors and lymphoid cells from hPSCs for immunotherapy through enhancing arterial programming of HE. [22May2018 Cell Reports]

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Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential

“A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development” – Daley (BCH) Research Hub 03

Drs. George Daley, Marcella Cesana, Michael Guo, and colleagues reported that hematopoietic stem cells (HSCs) manifest distinct alternative splicing patterns in key hematopoietic regulators. [05Apri2018 Cell Stem Cell]

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A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development

“Cardiac Recovery via Extended Cell-Free Delivery of Extracellular Vesicles Secreted by Cardiomyocytes Derived from Induced Pluripotent Stem Cells”

 

Drs. Bohao Liu, Benjamin Lee, Gordana Vunjak-Novakovic, and colleagues demonstrated that sustained delivery of extracellular vesicles, secreted by iPSC-derived cardiomyocytes, promote cardiac recovery after myocardial infarction. [23April2018 Nature Biomedical Engineering]

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