2nd Annual PCTC Meeting, September 27-28, 2018

2nd Annual PCTC Meeting

Meeting Location: 

NewYork-Presbyterian / Columbia University Irving Medical Center

Vivian and Seymour Milstein Family Heart Center

Myrna L. Daniels Auditorium,1st floor

173 Fort Washington Avenue, New York, NY 10032

http://www.nypheart.org/milstein/

Dates: September 27-28, 2018

Local Host: Dr. Hans-Willem Snoeck (hs2680@columbia.edu)

Steering Committee Meeting in Washington, DC - April 26, 2018

PCTC Steering Committee Meeting: Thursday, April 26, 2018
Location: National Academy of Sciences (NAS) Building,
[Room: NAS Lecture Room] 
2101 Constitution Ave, NW, Washington, DC 20418


Publication: Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Yang and colleagues (Cardoso’s lab) report on how basal cells emerge during development  and how a subset of  these progenitors mediate the pathological alveolar remodeling after influenza injury.

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Y. Yang, P. Riccio, M. Schotsaert, M. Mori, J. Lu, D-K. Lee ,A. Garcıa-Sastre, J. Xu, and W.V. Cardoso. Developmental Cell 44, 752–761, March 26, 2018

Link to full article:

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

Darrell Kotton, Ed Morrisey, and colleagues show that human pluripotent stem cell-derived airway epithelial spheres contain basal and secretory airway cells.

Read More:

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

“A Humanized Mouse Model Generated Using Surplus Neonatal Tissue” – Thomson (UW-M) Research Hub 05

Drs. Matthew Brown, Ying Zhou, James Thomson, and colleagues have created a humanized mouse model using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). [22Mar2018 Stem Cell Reports]

Link to full article:

http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30102-4

Publication: “Regeneration of the Lung Alveolus by an Evolutionarily Conserved Epithelial Progenitor”

Drs. Edward Morrisey, William Zacharias, David Frank, et al. demonstrate alveolar epithelial progenitors’ contribution to functional alveolar epithelial regeneration. [08Mar2018 Nature]

Link to full article:

https://www.nature.com/articles/nature25786

AEPs display an evolutionarily conserved response to Wnt and Fgf signaling.

 

PCTC “Jump-Start” Awards

PCTC Jump Start Award Program

Purpose:

To provide the PCTC with a mechanism to quickly award small grants to junior faculty (less than 5 years from their appointment to Assistant Professor), Research Associates, Graduate Students, Fellows and Postdocs to support a well-defined specific aim. The aim should involve at least one of the following, with priority given to proposals that incorporate two:

1.     The application of new technology to an existing translational research question

Request for Information (RFI): Strategically Critical Resources or Infrastructures Recommended for NHLBI Support Using the R24/U24 Grant Mechanisms

The NHLBI is requesting information on needs for resources or infrastructure to access biospecimens, disease models (cell lines or model organisms), production capabilities, information or data, or standardization of data/tools of relevance to the research mission of the NHLBI. Of particular interest are needs at a national level that could be supported under R24/U24 grant mechanisms.

Publication: “Dye-Independent Methods Reveal Elevated Mitochondrial Mass in Hematopoietic Stem Cells”

Drs. Hans-Willem Snoeck, Mariana Justino de Almeida, Larry Luchsinger, and colleagues correct the erroneous impression that HSCs have low mitochondrial content. HSCs exhibit high mitochondrial content yet possess limited respiratory and turnover capacity. [07Dec2017 Cell Stem Cell]

Link to full article:

http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30454-X

 

Pages

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