Jianyi “Jay” Zhang, MD, PhD
U01 Principal Investigator, 1-U01HL134764-01
Integrated Cellular and Tissue Engineering for Ischemic Heart Disease
Ischemic heart disease continues to have a tremendous impact on public health, shortening lifespan and impairing the quality of life. The inability of the adult human myocardium to undergo regeneration after a myocardial infarction has inspired research using cell therapy for myocardial repair. However, clinical trials to date have shown modest or no benefit, suggesting the need to consider other cell sources and approaches. In large animal models, derivatives of human pluripotent stem cells have provided promising results, but the grafts have generally been small, transient, and of limited functional benefit. In addition, there remain important questions regarding cardiac cells derived from iPSCs, including the optimal delivery strategy, immunogenicity, maturity, and the ability to couple effectively to the native myocardium without causing arrhythmias. In this proposal, three integrated projects will address these challenges and advance toward the long-term goal of utilizing a functional human cardiac tissue patch (hCTP) for repair of ischemic myocardium. The first project aims to generate novel cell populations, including induced cardiac progenitor cells and genetically engineered cell lines that will be evaluated for their immunogenicity in a novel humanized mouse model. These and other cell products, including commercially available sources, will be utilized to generate large vascularized hCTPs in the second project. The third project will utilize a porcine post-infarction model to test hCTPs and optimize electrical and vascular integration as assessed by optical mapping technology and MRI/NMR spectroscopy, respectively. These studies will overcome critical barriers to generating large, fully functional human cardiac tissues that can be integrated safely into the native myocardium to provide a powerful new approach for treatment of advanced ischemic heart disease.
User Name | Full Name | Institute Affiliation | Topic tags | People tags | |
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jzhang | Jianyi (Jay) Zhang, M.D., Ph.D. | University of Alabama | heart, left ventricular remodeling, myocardial energetics |
User Name | Full Name | Institute Affiliation | Topic tags | People tags | |
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nbursac | Nenad Bursac, PhD | Duke University | |||
tkamp | Timothy Kamp, M.D., Ph.D. | University of Wisconsin-Madison |
User Name | Full Name | Institute Affiliation | Topic tags | People tags | |
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lAgao | Ling Gao Ph.D. | University of Alabama at Birmingham | |||
sajinagc | Sajina GC | UAB | |||
ahelfer | Abbi Helfer | UAB | |||
AAkrell | Asher Krell | University of Alabama at Birmingham | |||
kyah27 | Rachel | University of Alabama at Birmingham | |||
Thanh Nguyen | Thanh Nguyen, PhD | UAB | |||
YAoduk | Yasin Oduk Ph.D | University of Alabama at Birmingham | |||
ezhang | Eric Zhang, PhD | University of Alabama |
User Name | Full Name | Institute Affiliation | Topic tags | People tags | |
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ccrowe | Christina Crowe, MA | UAB | |||
kellyh | Kelly Hillard | UAB |
User Name | Full Name | Institute Affiliation | Topic tags | People tags | |
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AAborovjagin | Anton V Borovjagin M.Sc., Ph.D | University of Alabama at Birmingham | |||
yingge | Ying Ge, Ph.D. | Department of Cell and Regenerative Biology Department of Chemistry Director of Mass Spectrometry Human Proteomics Program University of Wisconsin-Madison | |||
ynakada | Yuji Nakada, Ph.D. | UAB | |||
gqin | Gangjian Qin, MD | University of Alabama at Birmingham | |||
rajnsr | NS Rajasekaran | The University of Alabama at Birmingham | |||
ajnsr | Rajasekaran Namakkal | UAB | |||
Lei Ye | Lei Ye, MD | UAB | |||
JianZhang | Jianhua Zhang Ph.D. | University of Wisconsin-Madison | |||
yzhou | Yang Zhou, PhD | University of Alabama | |||
WuqiZhu | Wuqiang Zhu M.D. Ph.D. | University of Alabama at Birmingham |
Copyright ©2016 NHLBI Progenitor Cell Translational Consortium.