Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28

Longfei Wang, R. Grant Rowe, George Daley
Publication Type: 
Original Research Article
Name of Journal, Book, etc.: 
Cell Reports

Drs. Longfei Wang, R. Grant Rowe, George Daley, and colleagues report on the selective pharmacologic inhibition of individual domains of LIN28 and provide a foundation for therapeutic inhibition of the let-7 biogenesis pathway in LIN28-driven diseases. [05June2018 Cell Reports]

Copyright ©2016 NHLBI Progenitor Cell Translational Consortium.

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