Research Hub Principal Investigators

The Progenitor Cell Translational Consortium's lead principal investigators.

hchapman's picture
Harold (Hal) Chapman, MD
UCSF School of Medicine
Recent publications:

Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.
Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA.Thorax. 2021 Jan 20:thoraxjnl-2020-215745. doi: 10.1136/thoraxjnl-2020-215745. Online ahead of print.PMID: 33472968

T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue.
Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV.J Immunol. 2020 Oct 15;205(8):2026-2038. doi: 10.4049/jimmunol.2000114. Epub 2020 Sep 16.PMID: 32938729

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion.
Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL.Nat Commun. 2020 Sep 9;11(1):4520. doi: 10.1038/s41467-020-18298-8.PMID: 32908154

schou's picture
Stella Chou, M.D.
The Children's Hospital of Philadelphia
Recent publications:

Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K matched transfusions.
Waldis SJ, Uter S, Kavitsky D, Flickinger C, Vege S, Friedman DF, Westhoff CM, Chou ST.Blood Adv. 2021 Feb 9;5(3):737-744. doi: 10.1182/bloodadvances.2020003732.PMID: 33560383

Transfusion and Cellular Therapy in Pediatric Sickle Cell Disease.
Zheng Y, Chou ST.Clin Lab Med. 2021 Mar;41(1):101-119. doi: 10.1016/j.cll.2020.10.007. Epub 2020 Dec 24.PMID: 33494879

VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects.
Seu KG, Trump LR, Emberesh S, Lorsbach RB, Johnson C, Meznarich J, Underhill HR, Chou ST, Sakthivel H, Nassar NN, Seu KJ, Blanc L, Zhang W, Lutzko CM, Kalfa TA.Am J Hum Genet. 2020 Dec 3;107(6):1149-1156. doi: 10.1016/j.ajhg.2020.10.013. Epub 2020 Nov 12.PMID: 33186543

gdaley's picture
George Q. Daley, M.D., Ph.D.
Children's Hospital Boston
Recent publications:

SARS-CoV-2 viral load is associated with increased disease severity and mortality.
Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, Worrall D, Giguel F, Piechocka-Trocha A, Atyeo C, Fischinger S, Chan A, Flaherty KT, Hall K, Dougan M, Ryan ET, Gillespie E, Chishti R, Li Y, Jilg N, Hanidziar D, Baron RM, Baden L, Tsibris AM, Armstrong KA, Kuritzkes DR, Alter G, Walker BD, Yu X, Li JZ; Massachusetts Consortium for Pathogen Readiness.Nat Commun. 2020 Oct 30;11(1):5493. doi: 10.1038/s41467-020-19057-5.PMID: 33127906

Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI.Sci Transl Med. 2020 Oct 21;12(566):eabb5831. doi: 10.1126/scitranslmed.abb5831.PMID: 33087503

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting.
Lopes C, Tang Y, Anjo SI, Manadas B, Onofre I, de Almeida LP, Daley GQ, Schlaeger TM, Rego ACC.Front Cell Dev Biol. 2020 Sep 22;8:576592. doi: 10.3389/fcell.2020.576592. eCollection 2020.PMID: 33072759

hsnoeck's picture
Hans-Willem Snoeck, MD, PhD
Columbia University Health Sciences
Recent publications:

Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.
Hozain AE, O'Neill JD, Pinezich MR, Tipograf Y, Donocoff R, Cunningham KM, Tumen A, Fung K, Ukita R, Simpson MT, Reimer JA, Ruiz EC, Queen D, Stokes JW, Cardwell NL, Talackine J, Kim J, Snoeck HW, Chen YW, Romanov A, Marboe CC, Griesemer AD, Guenthart BA, Bacchetta M, Vunjak-Novakovic G.Nat Med. 2020 Jul;26(7):1102-1113. doi: 10.1038/s41591-020-0971-8. Epub 2020 Jul 13.PMID: 32661401

Calcium regulation of stem cells.
Snoeck HW.EMBO Rep. 2020 Jun 4;21(6):e50028. doi: 10.15252/embr.202050028. Epub 2020 May 17.PMID: 32419314

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.
Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE.Cell Stem Cell. 2020 Apr 2;26(4):482-502. doi: 10.1016/j.stem.2020.03.009.PMID: 32243808

jwhitsett's picture
Jeffrey A. Whitsett, M.D.
Recent publications:

Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium.
Li E, Ustiyan V, Wen B, Kalin GT, Whitsett JA, Kalin TV, Kalinichenko VV.Dev Dyn. 2021 Jan 11. doi: 10.1002/dvdy.298. Online ahead of print.PMID: 33428297

Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance.
Du Y, Ouyang W, Kitzmiller JA, Guo M, Zhao S, Whitsett JA, Xu Y.Am J Respir Cell Mol Biol. 2021 Jan;64(1):146-149. doi: 10.1165/rcmb.2020-0308LE.PMID: 33385216

In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation.
Wen B, Li E, Ustiyan V, Wang G, Guo M, Na CL, Kalin GT, Galvan V, Xu Y, Weaver TE, Kalin TV, Whitsett JA, Kalinichenko VV.Am J Respir Crit Care Med. 2021 Feb 15;203(4):471-483. doi: 10.1164/rccm.201909-1836OC.PMID: 32877203

jzhang's picture
Jianyi (Jay) Zhang, M.D., Ph.D.
University of Alabama
Recent publications:

Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine.
Gao L, Wang L, Wei Y, Krishnamurthy P, Walcott GP, Menasché P, Zhang J.Sci Transl Med. 2020 Sep 16;12(561):eaay1318. doi: 10.1126/scitranslmed.aay1318.PMID: 32938792

CHIR99021 and fibroblast growth factor 1 enhance the regenerative potency of human cardiac muscle patch after myocardial infarction in mice.
Fan C, Tang Y, Zhao M, Lou X, Pretorius D, Menasche P, Zhu W, Zhang J.J Mol Cell Cardiol. 2020 Apr;141:1-10. doi: 10.1016/j.yjmcc.2020.03.003. Epub 2020 Mar 10.PMID: 32169551

Deciphering Role of Wnt Signalling in Cardiac Mesoderm and Cardiomyocyte Differentiation from Human iPSCs: Four-dimensional control of Wnt pathway for hiPSC-CMs differentiation.
Zhao M, Tang Y, Zhou Y, Zhang J.Sci Rep. 2019 Dec 18;9(1):19389. doi: 10.1038/s41598-019-55620-x.PMID: 31852937

jthomson's picture
James A. Thomson, M.D., Ph.D.
University of Wisconsin
Recent publications:

Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis.
Seirup M, Chu LF, Sengupta S, Leng N, Browder H, Kapadia K, Shafer CM, Duffin B, Elwell AL, Bolin JM, Swanson S, Stewart R, Kendziorski C, Thomson JA, Bacher R.PLoS One. 2020 Sep 28;15(9):e0239711. doi: 10.1371/journal.pone.0239711. eCollection 2020.PMID: 32986734

Biologically Functionalized Expanded Polytetrafluoroethylene Blood Vessel Grafts.
Wang D, Xu Y, Lin YJ, Yilmaz G, Zhang J, Schmidt G, Li Q, Thomson JA, Turng LS.Biomacromolecules. 2020 Sep 14;21(9):3807-3816. doi: 10.1021/acs.biomac.0c00897. Epub 2020 Aug 21.PMID: 32786520

Expanded Poly(tetrafluoroethylene) Blood Vessel Grafts with Embedded Reactive Oxygen Species (ROS)-Responsive Antithrombogenic Drug for Elimination of Thrombosis.
Wang D, Xu Y, Wang L, Wang X, Ren C, Zhang B, Li Q, Thomson JA, Turng LS.ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29844-29853. doi: 10.1021/acsami.0c07868. Epub 2020 Jun 18.PMID: 32496045

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