Research Hub Principal Investigators

Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K matched transfusions.
Waldis SJ, Uter S, Kavitsky D, Flickinger C, Vege S, Friedman DF, Westhoff CM, Chou ST.Blood Adv. 2021 Feb 9;5(3):737-744. doi: 10.1182/bloodadvances.2020003732.PMID: 33560383

Transfusion and Cellular Therapy in Pediatric Sickle Cell Disease.
Zheng Y, Chou ST.Clin Lab Med. 2021 Mar;41(1):101-119. doi: 10.1016/j.cll.2020.10.007. Epub 2020 Dec 24.PMID: 33494879

VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects.
Seu KG, Trump LR, Emberesh S, Lorsbach RB, Johnson C, Meznarich J, Underhill HR, Chou ST, Sakthivel H, Nassar NN, Seu KJ, Blanc L, Zhang W, Lutzko CM, Kalfa TA.Am J Hum Genet. 2020 Dec 3;107(6):1149-1156. doi: 10.1016/j.ajhg.2020.10.013. Epub 2020 Nov 12.PMID: 33186543

SARS-CoV-2 viral load is associated with increased disease severity and mortality.
Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, Worrall D, Giguel F, Piechocka-Trocha A, Atyeo C, Fischinger S, Chan A, Flaherty KT, Hall K, Dougan M, Ryan ET, Gillespie E, Chishti R, Li Y, Jilg N, Hanidziar D, Baron RM, Baden L, Tsibris AM, Armstrong KA, Kuritzkes DR, Alter G, Walker BD, Yu X, Li JZ; Massachusetts Consortium for Pathogen Readiness.Nat Commun. 2020 Oct 30;11(1):5493. doi: 10.1038/s41467-020-19057-5.PMID: 33127906

Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI.Sci Transl Med. 2020 Oct 21;12(566):eabb5831. doi: 10.1126/scitranslmed.abb5831.PMID: 33087503

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting.
Lopes C, Tang Y, Anjo SI, Manadas B, Onofre I, de Almeida LP, Daley GQ, Schlaeger TM, Rego ACC.Front Cell Dev Biol. 2020 Sep 22;8:576592. doi: 10.3389/fcell.2020.576592. eCollection 2020.PMID: 33072759

Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.
Hozain AE, O'Neill JD, Pinezich MR, Tipograf Y, Donocoff R, Cunningham KM, Tumen A, Fung K, Ukita R, Simpson MT, Reimer JA, Ruiz EC, Queen D, Stokes JW, Cardwell NL, Talackine J, Kim J, Snoeck HW, Chen YW, Romanov A, Marboe CC, Griesemer AD, Guenthart BA, Bacchetta M, Vunjak-Novakovic G.Nat Med. 2020 Jul;26(7):1102-1113. doi: 10.1038/s41591-020-0971-8. Epub 2020 Jul 13.PMID: 32661401

Calcium regulation of stem cells.
Snoeck HW.EMBO Rep. 2020 Jun 4;21(6):e50028. doi: 10.15252/embr.202050028. Epub 2020 May 17.PMID: 32419314

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.
Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE.Cell Stem Cell. 2020 Apr 2;26(4):482-502. doi: 10.1016/j.stem.2020.03.009.PMID: 32243808

Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium.
Li E, Ustiyan V, Wen B, Kalin GT, Whitsett JA, Kalin TV, Kalinichenko VV.Dev Dyn. 2021 Jan 11. doi: 10.1002/dvdy.298. Online ahead of print.PMID: 33428297

Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance.
Du Y, Ouyang W, Kitzmiller JA, Guo M, Zhao S, Whitsett JA, Xu Y.Am J Respir Cell Mol Biol. 2021 Jan;64(1):146-149. doi: 10.1165/rcmb.2020-0308LE.PMID: 33385216

In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation.
Wen B, Li E, Ustiyan V, Wang G, Guo M, Na CL, Kalin GT, Galvan V, Xu Y, Weaver TE, Kalin TV, Whitsett JA, Kalinichenko VV.Am J Respir Crit Care Med. 2021 Feb 15;203(4):471-483. doi: 10.1164/rccm.201909-1836OC.PMID: 32877203

Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine.
Gao L, Wang L, Wei Y, Krishnamurthy P, Walcott GP, Menasché P, Zhang J.Sci Transl Med. 2020 Sep 16;12(561):eaay1318. doi: 10.1126/scitranslmed.aay1318.PMID: 32938792

CHIR99021 and fibroblast growth factor 1 enhance the regenerative potency of human cardiac muscle patch after myocardial infarction in mice.
Fan C, Tang Y, Zhao M, Lou X, Pretorius D, Menasche P, Zhu W, Zhang J.J Mol Cell Cardiol. 2020 Apr;141:1-10. doi: 10.1016/j.yjmcc.2020.03.003. Epub 2020 Mar 10.PMID: 32169551

Deciphering Role of Wnt Signalling in Cardiac Mesoderm and Cardiomyocyte Differentiation from Human iPSCs: Four-dimensional control of Wnt pathway for hiPSC-CMs differentiation.
Zhao M, Tang Y, Zhou Y, Zhang J.Sci Rep. 2019 Dec 18;9(1):19389. doi: 10.1038/s41598-019-55620-x.PMID: 31852937