Progenitor Cell Biology Consortium (PCBC) Cell Differentiation Data Available for Access

The Progenitor Cell Biology Consortium (PCBC), is a NHLBI sponsored effort to identify and characterize progenitor cell lineages, to direct the differentiation of stem and progenitor cells to desired cell fates, and to develop new strategies to address the unique challenges presented by the transplantation of these cells.

All materials, including raw data, metadata, analysis and processing code, and methodological and provenance documentation are publicly available for re-use and interactive exploration at Synapse: https://www.synapse.org/pcbc. The goal is to provide data that can improve our ability to robustly and reproducibly use human pluripotent stem cells to understand development and disease.

SYNAPSE: Portal Content: Data, Results, Models

The Synapse portal distributes data, results and analytical tools for the centrally characterized cell lines by the Cincinnati Cell Characterization Core (C4) as well as those generated by PCBC Hub Sites in collaboration with the Bioinformatics Core.

This portal aims to distribute both raw and processed data in computational form, by describing the processing of the data including experimental protocols. We provide educational material and best practices when analyzing the PCBC 'omics' data as well as tools to explore and analyze existing datasets including interactive visualizations of the methylation, gene expression and micro-RNA expression for all of the C4 data.

CORRESPONDING PUBLICATIONS:

Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium

Molecular, Phenotypic, and Sample-associated Data to Describe Pluripotent Stem Cell Lines and Derivatives