Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells
posted by sitemanager
on Fri, 11/09/2018 - 11:28am
Research hub:
Publication Type:
Original Research Article
Name of Journal, Book, etc.:
Leukemia
Year:
2018
PMID Reference:
Drs. Sarah K. Tasian, Jessica A. Casas, Stella Chou, and colleagues assessed whether MEK, JAK, and PI3K/mTOR kinase inhibitors could inhibit myeloproliferation and aberrant signaling in iPSC-derived hematopoietic progenitors with PTPN11 E76K or CBL Y371H mutation and demonstrated differential sensitivity.
Copyright ©2016 NHLBI Progenitor Cell Translational Consortium.
