Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells

Sarah K. Tasian, Jessica A. Casas, Stella Chou
Publication Type: 
Original Research Article
Name of Journal, Book, etc.: 

Drs. Sarah K. Tasian, Jessica A. Casas, Stella Chou, and colleagues assessed whether MEK, JAK, and PI3K/mTOR kinase inhibitors could inhibit myeloproliferation and aberrant signaling in iPSC-derived hematopoietic progenitors with PTPN11 E76K or CBL Y371H mutation and demonstrated differential sensitivity. 

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