CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle

Drs. Jianyi (Jay) Zhang, Wuqiang Zhu, Meng Zhao, and colleagues report that CCND2 overexpression activates cell-cycle progression in hiPSC-CMs to enhance potency for myocardial repair as evidenced by remuscularization of injured myocardium. [10Oct2017 Circulation Research]

Article was selected as a finalist for "The Melvin L. Marcus Young Investigator Award in Basic Cardiovascular Sciences” at the 2017 American Heart Association Meeting in Anaheim, California (Nov 9-16, 2017).

Link to full article:

http://circres.ahajournals.org/content/early/2017/10/09/CIRCRESAHA.117.311504.abstract?ijkey=4aHVtRnHYzG3F3I&keytype=ref

Figure 4. Cell-cycle activity and proliferation are greater in hiPSC-CCND2OECMs than in hiPSCCCND2WTCMs at week 4 after transplantation.

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