11:00 AM |
11:10 AM |
A Brief Overview of Multi-‘Omics: Technologies and Applications – Minzhe Guo |
11:10 AM |
11:30 AM |
Heart Presentation· SeATAC: a Tool for Exploring the Chromatin Landscape and the Role of Pioneer Factors – Wuming Gong |
11:30 AM |
11:50 AM |
Lung Presentation· The Human Respiratory Airways in Lung Development, Injury and Repair– Maria Basil |
11:50 AM |
12:10 PM |
Blood Presentation· Probing Niche Signals in HSC Development Using Single Cell Approaches – Brandon Hadland |
12:10 PM |
12:30 PM |
Commentary and Discussion |
1:30 PM |
1:45 PM |
Introduction and Overview of Bioengineering – Gordana Vunjak-Novakovic |
1:45 PM |
1:55 PM |
Heart Presentation I· Single Cell Transcriptomics in Neonatal Heart Development and Repair – Miao Cui |
1:55 PM |
2:05 PM |
Heart Presentation II· Remuscularization of Acute Myocardial Infarction by Activating the Cell Cycle in Cardiomyocytes: CCND2 Modified RNA in Small and Large Mammals – Jiacheng (Jason) Sun |
2:05 PM |
2:15 PM |
Lung Presentation· iPSC-derived Airway Stem Cells to Study and Achieve Lung Regeneration – Finn Hawkins |
2:15 PM |
2:25 PM |
Blood Presentation· Understanding HSC Development and Clinical Evolution Using iPSCs – Sergei Doulatov |
2:25 PM |
3:00 PM |
Commentary and Discussion |
8:00 AM |
9:30 AM |
Session I: Pluripotent Stem Cell Technologies to Advance Cardiovascular TherapiesDan Garry, moderator· Generation of an Off-the-Shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft – John Maufort· O-GlcNAcylation Promotes Angiogenic Transdifferentiation to Reverse Ischemia – Li Lai· Evading Immune-Mediated Allorejection of PSC-Cardiovascular Therapies – Matthew Brown· Cellular and Methodological Improvements to Model Heart Disease Using iPSCs in 3D – Jared Churko |
9:30 AM |
10:00 AM |
BREAK |
10:00 AM |
11:30 AM |
Session II: Activating Cardiac Repair in the Injured HeartNenad Bursac, moderator· Understanding and Improving Direct Cardiac Reprogramming – Yang Zhou· Stem Cells For Cardiovascular Regenerative Medicine: Translating Discovery to Product – Pratik Lalit· Deciphering the Code for Cardiomyocyte Proliferation – Tamer Mohamed· ETV2 is a Pioneer Transcription Factor for the Endothelial Lineage – Satya Das· Deep Learning Infers Cell-dependent RNA Velocity through a Relay Velocity Model – Guangyu Wang |
11:30 AM |
12:00 PM |
Discussion and Future Directions in Progenitor Cell Research and Therapy |
8:00 AM |
8:05 AM |
Introduction – Len Zon |
8:05 AM |
8:35 AM |
Reprogramming Session – Nancy Speck, moderator· Engineering Hematopoietic-specific Vascular Niche for Stem Cell Regeneration – Shahin Rafii· Interrogation of Arterial Programming in Hemogenic Endothelium for Generation of Lymphoid Cells – Igor Slukvin· Derivation of Improved Human Stem Cells for Hematovascular Regenerative Medicine – Elias Zambidis |
8:35 AM |
8:50 AM |
Discussion |
8:50 AM |
9:30 AM |
HSC Development Session – George Daley, moderator· High Resolution Analysis of Hematopoietic Development – Fernando Camargo· Microenvironmental Regulation of Developmental Hematopoietic Stem Cell Development Production – Trista North· Determining the Balance between Hematopoietic Stem and Progenitor Cell Formation in the Dorsal Aorta – Nancy Speck· Recapitulation of Hematopoietic Development with Human Pluripotent Stem Cells – Christopher Sturgeon |
9:30 AM |
9:45 AM |
Discussion |
9:45 AM |
10:25 AM |
Hematopoiesis Session – Shahin Rafii, moderator· Erythroid Self-Renewal – Jim Palis· The Stem Cell Niche – Len Zon· Paving the Way for Generating Self-Renewing Human Hematopoietic Stem Cells – Hanna Mikkola· Thymic Niche and Immune Regeneration – David Scadden |
10:25 AM |
10:40 AM |
Discussion |
10:40 AM |
11:30 AM |
Translational Session – Stella Chou and George Daley, co-moderators· Bringing hiPSC Derived Blood Cell Products to the Clinic: Platelets and CAR-T Cells – Thorsten Schlaeger· iPSC Models for Pediatric Blood Diseases – Stella Chou· Off the Shelf Adaptive Immunotherapies from iPSCs – George Daley· Hematopoietic Stem Cells as Models for Blood and Immune Disease Pathogenesis, including cD47 on Pathogenic Cells – Irv Weissman· DLK1, a Master Regulator of Stem Cells with a Novel Mechanism of Action – Irv Bernstein |
11:30 AM |
11:55 AM |
Discussion/Next Steps |
8:00 AM |
8:45 AM |
Session I: Endogenous Regenerative Stem/Progenitor Cells in the Mouse and Human Lung (Including Mouse and Human Differences) – Purushothama Rao Tata, moderator· Transcriptional and Epigenetic Control of Lung Cells – Jichao Chen· Context-dependent Activation and Differentiation of Distal Lung Epithelial Progenitors – Jaymin Kathiriya· Essential Contributions of Endothelial Cells to Lung Regeneration – Terren Niethamer |
8:45 AM |
9:00 AM |
Discussion |
9:00 AM |
9:45 AM |
Session II: The Impact Of Lung Regeneration Research on Chronic Lung Disease Including Fibrosis – Carla Kim, moderator· Mechanistic Insight and Translational Strategies for Perinatal Lung Injury from Studies of the Non-Human Primate Rhesus Macaque – Will Zacharias· The Role of Endothelial Progenitor Cells in Neonatal Lung Diseases – Vladimir Kalinichenko· Alveolar Progenitor Cells in Homeostasis, Repair and Aging – Astrid Gillich |
9:45 AM |
10:00 AM |
Discussion |
10:00 AM |
10:45 AM |
Session III: Exogenous Stem Cell Engraftment – Jay Rajagopal, moderator· Cell Engraftment in Mouse Models as a Platform to Assess Progenitor Plasticity and Function – Andrew Vaughan· Engraftment of hPSC-derived Lung Progenitors in a Xenograft Rat Model – Valerio Dorrello· Durable Alveolar Engraftment of PSC-derived Lung Tip-like Cells into Immunocompetent Mice – Michael Herriges |
10:45 AM |
11:00 AM |
Discussion |
11:00 AM |
11:45 AM |
Session IV: New Models of Lung Development, Disease, and Repair-Regeneration – Anne-Karina Perl, moderator· Conditional Blastocyst Complementation of a Defective FOXA2 Lineage Promotes the Generation of Whole Lung – Mooney Mori· Engineering Complex Organoids to Study Pulmonary Vascular Disease – Mingxia Gu· Dissecting Epigenetic Control of Lung Stem Cells and Lung Disease – Christine Fillmore Brainson |
11:45 AM |
12:00 PM |
Discussion |
1:00 PM |
1:10 PM |
· The Democratization of RNA Therapeutics: How RNA Changes Cardiovascular Drug Development and Delivery – John Cooke |
1:10 PM |
1:25 PM |
· An mRNA Therapeutic to Reverse Cardiovascular Aging – Anahita Mojiri |
1:25 PM |
1:35 PM |
· Overview of Lung Translational Advances – Jeff Whitsett |
1:35 PM |
1:50 PM |
· Development of a Novel Cell Transplantation Therapy – Pulmonary Macrophage Transplantation – Paritha Arumugam |
1:50 PM |
2:00 PM |
· Brief Overview of Blood Translational Advances – George Daley |
2:00 PM |
2:15 PM |
· Translational Opportunities in Neonatal Hematology and Transfusion Medicine– Christopher Thom |
2:15 PM |
2:30 PM |
Commentary and Discussion |
Copyright ©2016 NHLBI Progenitor Cell Translational Consortium.