11:00 AM

11:10 AM

A Brief Overview of Multi-‘Omics: Technologies and Applications – Minzhe Guo

11:10 AM

11:30 AM

Heart Presentation

·       SeATAC: a Tool for Exploring the Chromatin Landscape and the Role of Pioneer Factors – Wuming Gong

11:30 AM

11:50 AM

Lung Presentation

·       The Human Respiratory Airways in Lung Development, Injury and Repair

– Maria Basil

11:50 AM

12:10 PM

Blood Presentation

·       Probing Niche Signals in HSC Development Using Single Cell Approaches – Brandon Hadland

12:10 PM

12:30 PM

Commentary and Discussion

1:30 PM

1:45 PM

Introduction and Overview of Bioengineering – Gordana Vunjak-Novakovic

1:45 PM

1:55 PM

Heart Presentation I

·       Single Cell Transcriptomics in Neonatal Heart Development and Repair – Miao Cui

1:55 PM

2:05 PM

Heart Presentation II

·       Remuscularization of Acute Myocardial Infarction by Activating the Cell   Cycle in Cardiomyocytes: CCND2 Modified RNA in Small and Large   Mammals – Jiacheng (Jason) Sun

2:05 PM

2:15 PM

Lung Presentation

·       iPSC-derived Airway Stem Cells to Study and Achieve Lung Regeneration – Finn Hawkins

2:15 PM

2:25 PM

Blood Presentation

·       Understanding HSC Development and Clinical Evolution Using iPSCs – Sergei Doulatov

2:25 PM

3:00 PM

Commentary and Discussion

8:00 AM

9:30 AM

Session I: Pluripotent Stem Cell Technologies to Advance Cardiovascular Therapies

Dan Garry, moderator

·       Generation of an Off-the-Shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft – John Maufort

·       O-GlcNAcylation Promotes Angiogenic Transdifferentiation to Reverse Ischemia – Li Lai

·       Evading Immune-Mediated Allorejection of PSC-Cardiovascular Therapies – Matthew Brown

·       Cellular and Methodological Improvements to Model Heart Disease Using iPSCs in 3D – Jared Churko

9:30 AM

10:00 AM

BREAK

10:00 AM

11:30 AM

Session II: Activating Cardiac Repair in the Injured Heart

Nenad Bursac, moderator

·       Understanding and Improving Direct Cardiac Reprogramming – Yang Zhou

·       Stem Cells For Cardiovascular Regenerative Medicine: Translating Discovery to Product – Pratik Lalit

·       Deciphering the Code for Cardiomyocyte Proliferation – Tamer Mohamed

·       ETV2 is a Pioneer Transcription Factor for the Endothelial Lineage – Satya Das

·       Deep Learning Infers Cell-dependent RNA Velocity through a Relay Velocity Model – Guangyu Wang

11:30 AM

12:00 PM

Discussion and Future Directions in Progenitor Cell Research and Therapy

8:00 AM

8:05 AM

Introduction – Len Zon

8:05 AM

8:35 AM

Reprogramming Session – Nancy Speck, moderator

·       Engineering Hematopoietic-specific Vascular Niche for Stem Cell Regeneration – Shahin Rafii

·       Interrogation of Arterial Programming in Hemogenic Endothelium for Generation of Lymphoid Cells – Igor Slukvin

·       Derivation of Improved Human Stem Cells for Hematovascular Regenerative Medicine – Elias Zambidis

8:35 AM

8:50 AM

Discussion

8:50 AM

9:30 AM

HSC Development Session – George Daley, moderator

·       High Resolution Analysis of Hematopoietic Development – Fernando Camargo

·       Microenvironmental Regulation of Developmental Hematopoietic Stem Cell Development Production – Trista North

·       Determining the Balance between Hematopoietic Stem and Progenitor Cell Formation in the Dorsal Aorta – Nancy Speck

·       Recapitulation of Hematopoietic Development with Human Pluripotent Stem Cells – Christopher Sturgeon

9:30 AM

9:45 AM

Discussion

9:45 AM

10:25 AM

Hematopoiesis Session – Shahin Rafii, moderator

·       Erythroid Self-Renewal – Jim Palis

·       The Stem Cell Niche – Len Zon

·       Paving the Way for Generating Self-Renewing Human Hematopoietic Stem Cells – Hanna Mikkola

·       Thymic Niche and Immune Regeneration – David Scadden

10:25 AM

10:40 AM

Discussion

10:40 AM

11:30 AM

Translational Session – Stella Chou and George Daley, co-moderators

·       Bringing hiPSC Derived Blood Cell Products to the Clinic: Platelets and CAR-T Cells – Thorsten Schlaeger

·       iPSC Models for Pediatric Blood Diseases – Stella Chou

·       Off the Shelf Adaptive Immunotherapies from iPSCs – George Daley

·       Hematopoietic Stem Cells as Models for Blood and Immune Disease Pathogenesis, including cD47 on Pathogenic Cells – Irv Weissman

·       DLK1, a Master Regulator of Stem Cells with a Novel Mechanism of Action – Irv Bernstein

11:30 AM

11:55 AM

Discussion/Next Steps

8:00 AM

8:45 AM

Session I: Endogenous Regenerative Stem/Progenitor Cells in the Mouse and Human Lung (Including Mouse and Human Differences) – Purushothama Rao Tata, moderator

·       Transcriptional and Epigenetic Control of Lung Cells – Jichao Chen

·       Context-dependent Activation and Differentiation of Distal Lung Epithelial Progenitors – Jaymin Kathiriya

·       Essential Contributions of Endothelial Cells to Lung Regeneration – Terren Niethamer

8:45 AM

9:00 AM

Discussion

9:00 AM

9:45 AM

Session II: The Impact Of Lung Regeneration Research on Chronic Lung Disease Including Fibrosis – Carla Kim, moderator

·       Mechanistic Insight and Translational Strategies for Perinatal Lung Injury from Studies of the Non-Human Primate Rhesus Macaque – Will Zacharias

·       The Role of Endothelial Progenitor Cells in Neonatal Lung Diseases – Vladimir Kalinichenko

·       Alveolar Progenitor Cells in Homeostasis, Repair and Aging – Astrid Gillich

9:45 AM

10:00 AM

Discussion

10:00 AM

10:45 AM

Session III: Exogenous Stem Cell Engraftment – Jay Rajagopal, moderator

·       Cell Engraftment in Mouse Models as a Platform to Assess Progenitor Plasticity and Function – Andrew Vaughan

·       Engraftment of hPSC-derived Lung Progenitors in a Xenograft Rat Model – Valerio Dorrello

·       Durable Alveolar Engraftment of PSC-derived Lung Tip-like Cells into Immunocompetent Mice – Michael Herriges

10:45 AM

11:00 AM

Discussion

11:00 AM

11:45 AM

Session IV: New Models of Lung Development, Disease, and Repair-Regeneration – Anne-Karina Perl, moderator

·       Conditional Blastocyst Complementation of a Defective FOXA2 Lineage Promotes the Generation of Whole Lung – Mooney Mori

·       Engineering Complex Organoids to Study Pulmonary Vascular Disease – Mingxia Gu

·       Dissecting Epigenetic Control of Lung Stem Cells and Lung Disease – Christine Fillmore Brainson

11:45 AM

12:00 PM

Discussion

1:00 PM

1:10 PM

·       The Democratization of RNA Therapeutics: How RNA Changes Cardiovascular Drug Development and Delivery – John Cooke

1:10 PM

1:25 PM

·       An mRNA Therapeutic to Reverse Cardiovascular Aging – Anahita Mojiri

1:25 PM

1:35 PM

·       Overview of Lung Translational Advances – Jeff Whitsett

1:35 PM

1:50 PM

·       Development of a Novel Cell Transplantation Therapy – Pulmonary Macrophage Transplantation – Paritha Arumugam

1:50 PM

2:00 PM

·       Brief Overview of Blood Translational Advances – George Daley

2:00 PM

2:15 PM

·       Translational Opportunities in Neonatal Hematology and Transfusion Medicine

 – Christopher Thom

2:15 PM

2:30 PM

Commentary and Discussion