2nd Annual PCTC Meeting, September 27-28, 2018

2nd Annual PCTC Meeting

Meeting Location: 

Vivian & Seymour Milstein Family Heart Center

Myrna Daniels Auditorium, 1st floor

173 Fort Washington Avenue, New York, NY 10032

Dates: September 27-28, 2018

Local Host: Dr. Hans-Willem Snoeck (hs2680@columbia.edu)






Steering Committee Meeting in Washington, DC - April 26, 2018

PCTC Steering Committee Meeting: Thursday, April 26, 2018
Location: National Academy of Sciences (NAS) Building,
[Room: NAS Lecture Room] 
2101 Constitution Ave, NW, Washington, DC 20418

Publication: “Regeneration of the Lung Alveolus by an Evolutionarily Conserved Epithelial Progenitor”

Drs. Edward Morrisey, William Zacharias, David Frank, et al. demonstrate alveolar epithelial progenitors’ contribution to functional alveolar epithelial regeneration. [08Mar2018 Nature]

Link to full article:


AEPs display an evolutionarily conserved response to Wnt and Fgf signaling.


PCTC “Jump-Start” Awards

PCTC Jump Start Award Program


To provide the PCTC with a mechanism to quickly award small grants to junior faculty (less than 5 years from their appointment to Assistant Professor), Research Associates, Graduate Students, Fellows and Postdocs to support a well-defined specific aim. The aim should involve at least one of the following, with priority given to proposals that incorporate two:

1.     The application of new technology to an existing translational research question

Request for Information (RFI): Strategically Critical Resources or Infrastructures Recommended for NHLBI Support Using the R24/U24 Grant Mechanisms

The NHLBI is requesting information on needs for resources or infrastructure to access biospecimens, disease models (cell lines or model organisms), production capabilities, information or data, or standardization of data/tools of relevance to the research mission of the NHLBI. Of particular interest are needs at a national level that could be supported under R24/U24 grant mechanisms.

Publication: “Dye-Independent Methods Reveal Elevated Mitochondrial Mass in Hematopoietic Stem Cells”

Drs. Hans-Willem Snoeck, Mariana Justino de Almeida, Larry Luchsinger, and colleagues correct the erroneous impression that HSCs have low mitochondrial content. HSCs exhibit high mitochondrial content yet possess limited respiratory and turnover capacity. [07Dec2017 Cell Stem Cell]

Link to full article:



Sustained miRNA Delivery from an Injectable Hydrogel Promotes Cardiomyocyte Proliferation and Functional Regeneration after Ischaemic Injury

Drs. Edward Morrisey, Leo Wang, Ying Liu, and colleagues report on an injectable hyaluronic acid hydrogel for local and sustained delivery of miR-302 mimics to the heart. [27Nov2017 Nature Biomedical Engineering]


Link to full article:


Hydrogel assembly and miR-302 interactions.


Training Opportunity: “Human Induced Pluripotent Stem Cells and Their Differentiation into Endoderm and Lung-Progeny” at Boston Medical Center (April 9-13, 2018)

The Center for Regenerative Medicine (CReM) at Boston University Medical Center is offering a five-day course that will focus on deriving, maintaining, characterizing and differentiating human induced pluripotent stem cells (hiPSCs). Small class size will enable researchers to learn the entire process of reprogramming from somatic cell preparation, to reprogramming methodologies, iPSC identification, isolation and characterization, and current approaches to their directed differentiation into endodermal and lung lineages.

“Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung”

Drs. Edward Morrisey, Jarod Zepp, William Zacharias, and colleagues report on the functional pathways that define the cellular and molecular framework of lung mesenchymal niches and reveal the functional importance of developmental pathways in promoting self-renewal versus a pathological response to tissue injury. [07Sep2017 Cell]


Link to full article:


“Cardiopatch Platform Enables Maturation and Scale-up of Human Pluripotent Stem Cell-derived Engineered Heart Tissues”

Drs. Nenad Bursac, Ilya Shadrin, Brian Allen, and colleagues report on a “Cardiopatch” platform for 3D culture and maturation of hiPSC-CMs (after 5 weeks of differentiation) showing robust electromechanical coupling, consistent H-zones, I-bands, and evidence for T-tubules and M-bands. [28Nov2017 Nature Communications]

Link to full article:




Copyright ©2016 NHLBI Progenitor Cell Translational Consortium.

University of Maryland School of Medicine logo

National Heart Blood and Lung Institute logo