2nd Annual PCTC Meeting, September 27-28, 2018

2nd Annual PCTC Meeting

Online registration for the 2nd Annual NHLBI Progenitor Cell Translational Consortium (PCTC) Meeting in New York, NY (Thursday, September 27, 2018 and Friday, September 28, 2018) is now open. We require a picture and brief description of your work for registration. These will be placed in the electronic booklet published on the PCTC website so colleagues with similar interests can identify you.

PCTC “Jump-Start” Awards

PCTC Jump Start Award Program

Purpose:

To provide the PCTC with a mechanism to quickly award small grants to junior faculty (less than 5 years from their appointment to Assistant Professor), Research Associates, Graduate Students, Fellows and Postdocs to support a well-defined specific aim. The aim should involve at least one of the following, with priority given to proposals that incorporate two:

1.     The application of new technology to an existing translational research question

“Cardiac Recovery via Extended Cell-Free Delivery of Extracellular Vesicles Secreted by Cardiomyocytes Derived from Induced Pluripotent Stem Cells”

 

Drs. Bohao Liu, Benjamin Lee, Gordana Vunjak-Novakovic, and colleagues demonstrated that sustained delivery of extracellular vesicles, secreted by iPSC-derived cardiomyocytes, promote cardiac recovery after myocardial infarction. [23April2018 Nature Biomedical Engineering]

Read More:

NHLBI 70th Anniversary Lecture Series

To commemorate the National Heart, Lung, and Blood Institute’s 70th anniversary, lectures throughout 2018 will feature leaders in areas of high scientific priority.

Upcoming lectures at the NIH main campus:

  • Dr. Eugene Braunwald, Brigham and Women’s Hospital

    • Thursday, June 28, 2018

  • Dr. Jonathan Samet, Colorado School of Public Health

    • Wednesday, September 12, 2018

  • Dr. Lisa Schwartz and Dr. Steven Woloshin, Dartmouth Institute

Publication: Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Yang and colleagues (Cardoso’s lab) report on how basal cells emerge during development  and how a subset of  these progenitors mediate the pathological alveolar remodeling after influenza injury.

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Y. Yang, P. Riccio, M. Schotsaert, M. Mori, J. Lu, D-K. Lee ,A. Garcıa-Sastre, J. Xu, and W.V. Cardoso. Developmental Cell 44, 752–761, March 26, 2018

Link to full article:

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

Darrell Kotton, Ed Morrisey, and colleagues show that human pluripotent stem cell-derived airway epithelial spheres contain basal and secretory airway cells.

Read More:

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

“A Humanized Mouse Model Generated Using Surplus Neonatal Tissue” – Thomson (UW-M) Research Hub 05

Drs. Matthew Brown, Ying Zhou, James Thomson, and colleagues have created a humanized mouse model using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). [22Mar2018 Stem Cell Reports]

Link to full article:

http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30102-4

Publication: “Regeneration of the Lung Alveolus by an Evolutionarily Conserved Epithelial Progenitor”

Drs. Edward Morrisey, William Zacharias, David Frank, et al. demonstrate alveolar epithelial progenitors’ contribution to functional alveolar epithelial regeneration. [08Mar2018 Nature]

Link to full article:

https://www.nature.com/articles/nature25786

AEPs display an evolutionarily conserved response to Wnt and Fgf signaling.

 

Request for Information (RFI): Strategically Critical Resources or Infrastructures Recommended for NHLBI Support Using the R24/U24 Grant Mechanisms

The NHLBI is requesting information on needs for resources or infrastructure to access biospecimens, disease models (cell lines or model organisms), production capabilities, information or data, or standardization of data/tools of relevance to the research mission of the NHLBI. Of particular interest are needs at a national level that could be supported under R24/U24 grant mechanisms.

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